Relative telomere length and cognitive decline in the Nurses’ Health Study
نویسندگان
چکیده
منابع مشابه
Relative telomere length and cognitive decline in the Nurses' Health Study.
Telomeres are short DNA repeats on the ends of mammalian chromosomes, which can undergo incomplete replication leading to gradual shortening with each cell cycle. Age and oxidative stress are contributors to telomere shortening; thus, telomere length may be a composite measure of biologic aging, and a potential predictor of health status in older adults. We evaluated whether relative telomere l...
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BACKGROUND Although cross-sectional studies have linked higher body mass index (BMI) and type 2 diabetes (T2D) to shortened telomeres, whether these metabolic conditions play a causal role in telomere biology is unknown. We therefore examined whether genetic predisposition to higher BMI or T2D was associated with shortened leukocyte telomere length (LTL). METHODOLOGY We conducted an analysis ...
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ژورنال
عنوان ژورنال: Neuroscience Letters
سال: 2011
ISSN: 0304-3940
DOI: 10.1016/j.neulet.2011.01.041